The Commissioner must refuse the request for leave to amend, if:
(a) he or she reasonably believes that a proposed amendment is not allowable, other than for the reasons mentioned in subregulation 10.2C(3); or
(b) the applicant or patentee has not complied with a request of the Commissioner under subregulation 10.1(3); or
(c) in the case of a proposed amendment of a complete specification relating to a patent--the patentee has not complied with a request of the Commissioner under subregulation 10.1(4).